Joe Rogan Talks about NMN with David Sinclair
NMN is not just a pill. It's a supplement that mimics fasting effects, it speeds up metabolism. It's excercise in a pill.
A molecule called NAD+ is found in every cell of your body and is essential for making energy. As we age, our levels of NAD+ decrease, which causes us to age faster and feel tired. NMN is the closest thing scientists have found to an anti-aging pill as it helps the body generate NAD+ levels similar to when we're young and our bodies are able to battle disease.
We're in late stage human trials for NMN. What we know is the NMN molecule is safe. And it raises NAD+.
What does NMN do for our body?
The NMN molecule is a coenzyme that helps produce NAD+, a compound that's essential to life. NAD+ is found in all living cells, where it plays a key role in converting food into energy and repairing DNA.
Scientists at Harvard Medical School have been studying the importance of NMN for more than 10 years. They've shown that human levels of NAD+ decline with age and have linked this decline to an increased risk for diabetes, heart disease, cancer and dementia.
NMN's goal is to rev up metabolism and fight aging and disease like we do when we're young. Our bodies fight against disease when were younger, there's a reason why we don't get heart disease or Alzheimer's when we're young. As we get older, especially when we don't have a health lifestyle, our bodies just give up.
NAD IV Drip VS. NMN Supplements
NAD+ is a coenzyme found in all living cells, and it's involved in many cellular processes. The NAD+/NADH ratio determines whether a cell is metabolizing nutrients for growth or repair.
NMN is a natural human metabolite that gets converted into NAD+. It can be taken orally, like a supplement, but it's not clear how much you need to take for it to have an effect. It's also possible to get NMN intravenously.
The difference is just the delivery route. They mostly work the same way. Nobody has put them head to head yet, but the assumption is it has the same effect.
Joe's experience with NAD+ IV Drips and Marijuana use
I used to do NAD+ IV drip and it was rough. It's a strange feeling and you get stomach cramps. It's possible to tolerate it with a fast drip, but most people do it for two hours. But marijuana changes the game. It makes it tolerable since it reduces nausea, and I did it in 10 minutes compared to my fastest without it for 30 minutes but it was a nightmare.
I've heard of people doing this at home, but I wouldn't recommend that because you need to be monitored by a doctor or nurse to ensure that you don't have an allergic reaction or any other issues like heart problems or blood pressure issues that could arise from IVs.
NAD+ and Jet Lag
Your body has separate clocks within your organs, and you'll feel like crap when it's out of sync. That's what jet lag does. It makes your body out of sync with each other. Your stomach might think that it's time to eat, while your brain is telling you to sleep. This puts you out of whack hence your tiredness and irritability.
NMN supplements are great for resetting your clock when you travel. It's really night and day. NAD levels cycle through the day. They go up in morning and get you ready. Then they wind down at night. You don't want these stuff injected at night because it will tell your body it's morning. Jet lag is caused by the disruption of the cycle of NAD+ going up and down in your body. This is why NMN supplement is great to reset your body when you travel. It's really night and day.
Exercise when your jet lag helps a lot too, but it really falls upon the body raising your NAD+ levels when you workout which brings your organs and your body back in sync with each other.
Get Better Sleep
More than half of all American adults experience symptoms of insomnia at least once a week. It's not just about being tired, though. Insomnia can have serious effects on your health and well-being, including an increased risk of depression, heart disease and obesity.
So what do you do if you're having trouble sleeping? A recent study suggests that taking supplements may help. The study was conducted by researchers at the University of California, San Francisco who were interested in how a molecule called NMN might affect sleep quality in mice.
it's already known that there are proteins in the cell that bind to genes that control your body's clock. They're regulated directly by the amount of NAD+ in the cell. If you manipulate NAD+ levels, that clock gets screwed up. As you get older, it naturally gets screwed up. We all know what happens as we age: It gets harder to fall asleep at night and stay asleep throughout the night.
One hope is that by raising NAD+, you get better sleep.
If you want to watch or listen to the full episode, check it out here!